WSU Biology Alzheimer Disease Essay

I want a summary of Alzheimer Disease that answer all or most of these:

• Questions to address:
• 1)
  Structure and pI of Abeta
• 2)
  How Abeta peptides are
  generated in the brain
• 3)
  Chronologic relation
  between Abeta 42 and 40 generation and the progression of Alzheimer’s disease
  pathology, vascular dementia, and Down syndrome.
• 4)
  The different morphology of
  mature plaque vs primitive plaque with different Abeta 42 and 40
• 5)
  Are bundles present in
  plaques with Abeta42, Abeta 40 or a mixture of the two kinds of peptides
• 6)
  Abeta 42 and 40 amyloid
  fiber formation pathways
• 7)
  Abeta 42 and 40 oligomers size, diameter and
  number of monomers
• 8)
  Abeta 42 and 40 mixture at
  different ratio and the effect on fiber formation
• 9)
  Speculate how abeta 40 may affect Abeta 42
  aggregation and formation of oligomers and fibers
• 10) Speculate how extracelluar matrix such as charged polymers and
  noncharged polymers affect fiber formation.
• 11) Guess or Speculate how metal (Copper, Zinc, Calcium) ions such
  as those found in the plaque
  affect the fiber formation
• 12) Speculate how lipid molecules affect fiber formation
• 13) Diagnostics for AD
• 14) Aβ degradation
• 15) Aβ forms and their toxicity
• 16) The amyloidhypothesis (AH)