Using information gleaned from your readings on Eicosanoids, give a clear biochemical response
to these questions (Your answers should not be more than 2 pages):
a. A 65 year old retired construction worker is referred to the dialysis clinic following a
recent diagnosis of chronic kidney disease due to a prolonged use of of the NSAID
Ibuprofen. Explain the biochemical basis of NSAID nephropathy?
b. What is the biochemical rationale for the use of low dose aspirin in patients with
coronary artery disease? Why is Ibuprofen not a good substitute for aspirin in this
You must give detailed and well-explained answers to the assignment questions for each module.
It is your responsibility to give clear, easy to understand and precise explanations in your
answers – you must be very convincing with your answers!
All assignment submissions should be consistent with the following;
Length of assignment – Not more than 2 pages
o The title and reference pages are excluded from the page count. No abstract is
Format of assignment – AMA
Number of citations – At least 3
Acceptable sources – Peer-reviewed Journal articles and textbooks